Anticipative Dynamics of a Retina

chi-keung chan^1,2*

¹Institute of Physics, Academia Sinica, Taipei, Taiwan
²Department of Physics, National Central University, Chungli, Taiwan

* Presenter:chi-keung chan, email:ckchan@gate.sinica.edu.tw

The anticipative properties of spikes generated by retinal ganglion cells (RGCs) of bull frogs have been studied in a multi-electrode array system with time varying whole field stimulation. Both predictable and non-predictable stimulations are used in the experiments. They are generated by a hidden Markov model (HMM) and an Ornstein–Uhlenbeck (OU) process respectively. Anticipative properties of these elicited spikes are characterized by the method of time lag mutual information between the stimulations and the spike trains. Our experiments show that only the predictable HMM stimulation can elicit anticipative responses from a retina and not all the RGCs can generate anticipative spikes. Experiments with on and off stimulations further indicate that anticipative responses are generated by the OFF-RGCs . A model based on time delayed negative feedback, also known as anticipatory relaxation dynamics (Voss, PRE 93, 030201(R), 2016) is used to understand our experiments. We find that anticipative responses of a retina might originate from the adaptation of retina to incoming light intensity.

Keywords: anticipation, retina, synchronization, dynamics